Use Chloroquine To Treat New Coronary Pneumonia? Several Issues We Must Understand

- Apr 08, 2020-

In view of the current severe COVID19 epidemic, the research and development of drugs and vaccines are also in full swing. Because some studies have shown that the anti-malarial drug "hydroxychloroquine" can treat new coronavirus infections, some politicians have "advocated" the use of hydroxychloroquine in the treatment of new coronary pneumonia. However, this opinion has been opposed by the group of doctors. Whether hydroxychloroquine can be used against neocoronavirus is still under debate. However, many scientists say that hydroxychloroquine is currently not recommended for treatment because there is too little supporting evidence.


What is the working mechanism of hydroxychloroquine?

In fact, this drug can help regulate an overactive immune system. Since the 1940s, hydroxychloroquine has been used to prevent and treat malaria, in addition to the treatment of rheumatoid arthritis and lupus. The "Plaquenil" currently sold in the United States is hydroxychloroquine.

What is the evidence supporting hydroxychloroquine in the treatment of new coronary pneumonia?

Some small, very preliminary studies have given conflicting results. A laboratory study showed that hydroxychloroquine inhibited the virus's ability to enter cells. Another report on 11 patients found that it did not improve the rate at which patients cleared the virus or its symptoms. A report from China stated that this drug provided effective treatment for more than 100 patients from 10 hospitals, but the severity of the disease was different for the patients who received the treatment, and the time and dose of the drug treatment were also different. In addition, because there is no suitable control group data, these patients have the possibility of self-healing.

Another study reported that the improvement rate of symptoms such as cough, pneumonia and fever became faster among 31 patients who received hydroxychloroquine compared with 31 patients in the control group. These results have been published, but have not yet been peer-reviewed.

Finally, the results of a small study from France that was recognized by US President Donald Trump "to prove that the drug is good" are currently being questioned.


What are the risks of hydroxychloroquine?

Hydroxychloroquine can cause heart rhythm problems, in addition to severe hypotension and muscle and nerve damage. Since laboratory research did not pay special attention to these issues, the risk of using the drug in the clinic was virtually increased. (Bio Valley