Nampt: linking NAD biology, metabolism and cancer
Antje Garten1, , Stefanie Petzold1, Antje Krner1, Shin-ichiro Imai2, and Wieland Kiess1
1University of Leipzig, Hospital for Children and Adolescents, Research Laboratory, Oststr. 21-25, 04317 Leipzig, Germany
2Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
(From Trends in Endocrinology & Metabolism doi:10.1016/j.tem.2008.10.004)