January 18, 2020, Recently, in a research report published in the international journal Frontiers in Oncology, scientists from Anschutz University School of Medicine and other institutions found that the name used by each cell in the body Glucose byproduct of lactic acid may promote canceration of mutant cells.
Image credit: National Institutes of Health
Researcher Inigo San Millan said that we found that lactic acid may serve as a catalyst to induce mechanisms in mutant cells, thereby opening the cell's cancerous process. Related research results may help elucidate the mechanism of cancer at the metabolic level. It is expected to help develop new therapies to effectively suppress cancer by targeting lactic acid. Lactic acid is not a waste, it is the main source of cellular energy, especially mitochondria.
About a century ago, scientists first described the key role of lactic acid in the development of cancer. At the time, Otto Warburg, a Nobel laureate, found that the main characteristic of cancer cells is not only the rapid depletion of glucose, but also It will also increase the production of lactic acid. This process is called "The Warburg Effect", but the specific mechanism of this effect is currently unknown to researchers. In 2017, researchers passed research Put forward a hypothesis that they revealed the significance of the Warburg effect, that is, the production of lactic acid for cancer formation.
Researchers San Millan and others then began to confirm this hypothesis. They exposed human breast cancer cells to glucose, which produces lactic acid, which increases the expression of all major mutant genes, and these genes are increased in breast cancer 150% -800%. We all know that not every mutated cell will become cancerous, and some studies have speculated which factors may induce the expression of mutated genes. Related research results show that lactic acid may be the key trigger. At present researchers in small cell lung cancer Research is being performed in cancer to clarify whether similar results will occur.
Researchers said that lactic acid may be a major signal molecule and gene regulator involved in cancer development, which is different from the lactic acid we produce during exercise. The lactic acid produced during exercise will be quickly metabolized by the body. It can improve the health of the body, and the amount of lactic acid produced during the cancer process remains the same. It will continue to produce and act as a Ruihua and to activate the mutant gene into the cancer. At present researchers are still not clear about it Specific molecular mechanisms.
Human muscle tissue is more resistant to the development of cancer. Exercise can actually reduce the risk of certain cancers and can treat some cancers. Now researchers have begun to apply personalized exercise programs to the treatment of cancer patients. They hope that this strategy will be used as part of a cancer rehabilitation plan, and that researchers will also explain in depth how exercise can help prevent and treat cancer. Researchers are also trying to find new ways to block lactic acid from leaving cancer cells.
When lactic acid is produced later, it will leave the cell through the transporter. The researchers want to study and try to use different compounds to block the formation of lactic acid in cancer cells and lactic acid in cancer cells. Will not form. But trying to use systemic drugs to block lactic acid in the body can be fatal, so researchers need more targeted treatment. In addition, lactic acid from cancer cells may also serve as a key "player" to keep the immune system attacking cancer cells continuously.
Finally, researcher San Millan said that they are currently studying in depth to try to block lactic acid produced by different cancers implanted in mice. If they can effectively target lactic acid, researchers may hope to develop new individuals to end cancer Chemotherapy. (from Bioon.com,compile hsppharma.com)
Iñigo San-Millán et al. Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells, Frontiers in Oncology (2020). DOI: 10.3389/fonc.2019.01536