Sitaxsentan Sodium CAS 210421-74-2

Sitaxsentan Sodium CAS 210421-74-2

CAS NO: 210421-74-2
Molecular Formula: C18H14ClN2NaO6S2
Molecular Weight: 476.886
EINECS NO: 606-692-6
MDL NO: MFCD11040990
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Product Details

Product Description

Product Name: Sitaxsentan sodium CAS 210421-74-2

 

 

Synonyms:

Thelin;

Sitax;

Sitaxentan sodium;

sodium,(4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide;

 

 

Chemical & Physical Properties

Appearance : white to off-white powder

Assay :≥98.0%

Water Solubility:H2O: soluble10mg/mL (clear solution)

 

 

Selective endothelin A (ETA) receptor antagonist. Antihypertensive. Used in treatment of chronic heart failure.

 

Sitaxentan sodium, belongs to thesulfonamide class of endothelin receptor antagonists.Although it has 6,000-fold selectivity for the ETA receptor,clinical trials have not demonstrated a greater efficacyover bosentan. However, it has much lower liver toxicitythan bosentan. The manufacturer is attempting to meetefficacy outcomes set by the FDA, which must be met beforeapproval of sitaxsentan as a therapeutic agent will begranted.

 

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

 

 


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