Sitaxsentan Sodium CAS 210421-74-2

Sitaxsentan Sodium CAS 210421-74-2

CAS NO: 210421-74-2
Molecular Formula: C18H14ClN2NaO6S2
Molecular Weight: 476.886
EINECS NO: 606-692-6
MDL NO: MFCD11040990
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Product Details

Product Description

Product Name: Sitaxsentan sodium CAS 210421-74-2






Sitaxentan sodium;




Chemical & Physical Properties

Appearance : white to off-white powder

Assay :≥98.0%

Water Solubility:H2O: soluble10mg/mL (clear solution)



Selective endothelin A (ETA) receptor antagonist. Antihypertensive. Used in treatment of chronic heart failure.


Sitaxentan sodium, belongs to thesulfonamide class of endothelin receptor antagonists.Although it has 6,000-fold selectivity for the ETA receptor,clinical trials have not demonstrated a greater efficacyover bosentan. However, it has much lower liver toxicitythan bosentan. The manufacturer is attempting to meetefficacy outcomes set by the FDA, which must be met beforeapproval of sitaxsentan as a therapeutic agent will begranted.



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