Ribociclib CAS 1211441-98-3

Ribociclib CAS 1211441-98-3

CAS NO: 1211441-98-3
Molecular Formula: C23H30N8O
Molecular Weight: 434.537
EINECS NO: 807-111-0
MDL NO: MFCD27976795
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Product Details

Product Description:

Product Name: Ribociclib CAS NO: 1211441-98-3




LEE 011;


Chemical & Physical Properties:

Appearance: White to off-white powder

Assay :≥99.0%


Boiling Point:730.8℃ at 760 mmHg

Flash Point:395.8℃

Solubility: Soluble in DMSO, not soluble in water.


Description: Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.


Related CAS#

1211441-98-3 (Ribociclib free base)

1211443-80-9 (Ribociclib hydrochloride)

1374639-75-4 (Ribociclib succinate)



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