Remdesivir CAS 1809249-37-3

Remdesivir CAS 1809249-37-3

CAS NO: 1809249-37-3
Molecular Formula: C27H35N6O8P
Molecular Weight: 602.576
EINECS NO: N/A
MDL NO:MFCD909249373
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Product Details

Product Description

Product Name: Remdesivir CAS NO: 1809249-37-3

 

 

Synonyms:

2-ethylbutyl (2S)-2-(((2R, 3S, 4R, 5R)-5-(4-aminopyrrolo(2,1-f) (1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl) methoxy)(phenoxy) phosphoryl) amino) propanoate;

GS 5734,GS-5734;

l-alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-d-altrononitrile;

(S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;

 

 

 

Chemical & Physical Properties

Appearance : Foamed solid

Assay : ≥99.0%,

Single impurity ≤0.1%

Total impurity ≤0.5%

Loss on drying ≤0.5%

Density:1.5g/cm3

 


Remdesivir is a nucleoside analogue. It is an RNA dependent RNA polymerase (RdRp) inhibitor. It can inhibit the synthesis of viral nucleic acid to resist virus infection. At present, the study of clinical chemical Book bed for Ebola virus infection has reached phase II. Mice infected with mers performed much better after this combination therapy, with reduced virus replication and improved lung function. Recent studies have shown that radcivir has a certain activity in inhibiting new coronavirus.

 

Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.

 

In Vitro:  Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h.

 

We can supply API and Intermediates,used to treatment of COVID-19 :


Product   Name

CAS NO:

Remdesivir 

1809249-37-3

(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile

1355357-49-1

(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol

1355049-94-3

GS   441524,(2R,3R,4S,5R)-2-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

1191237-69-0

D-Altrononitrile,   2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)

1191237-80-5

Remdesivir   intermediate

1191578-98-7

N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl   ester

1354823-36-1

Pyrrolo[2,1-f][1,2,4]triazin-4-amine

159326-68-8

2,3,5-Tri-O-benzyl-D-ribonolactone

55094-52-5

4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine

1770840-43-1 

7-bromopyrrolo[1,2-f][1,2,4]triazin-4-amine

 937046-98-5

(S)-2-ethylbutyl 2-aminopropanoate hydrochloride

 946511-97-3

Remdesivir   intermediate

1884576-18-4



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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

 

 


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