(R)-Rivaroxaban CAS 865479-71-6

(R)-Rivaroxaban CAS 865479-71-6

CAS NO: 865479-71-6
Molecular Formula: C19H18ClN3O5S
Molecular Weight: 435.88
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Product Details

Product Description:

Product Name: (R)-Rivaroxaban CAS NO:865479-71-6







Chemical & Physical Properties:

Appearance : White powder

Assay :≥97.0%

Density: 1.46g/cm3

Boiling Point:732.6℃at 760 mmHg

Flash Point:396.9℃


5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).

Rivaroxaban (BAY 59-7939) is an oral, direct Factor Xa (FXa) inhibitor in development for the prevention and treatment of arterial and venous thrombosis. Rivaroxaban competitively inhibits human FXa (Ki 0.4 nM) with >10 000-fold greater selectivity than for other serine proteases; it also inhibits prothrombinase activity (IC50 2.1 nM). Rivaroxaban inhibits endogenous FXa more potently in human and rabbit plasma (IC50 21 nM) than rat plasma (IC50 290 nM). It demonstrates anticoagulant effects in human plasma, doubling prothrombin time (PT) and activates partial thromboplastin time at 0.23 and 0.69 μM, respectively.

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