Obeticholic Acid CAS 459789-99-2

CAS No: 459789-99-2
Molecular Formula: C26H44O4
Molecular Weight: 420.625
EINECS NO: 810-245-2
MDL NO: MFCD16621104
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Product Details

Product Description:

Product Name: Obeticholic Acid CAS NO: 459789-99-2


Synonyms:

(3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic Acid; 

3α,7β-Dihydroxy-6α-ethyl-5β-cholan-24-oic Acid;



Chemical & Physical Properties:

Appearance : White to off-white crystalline powder

Assay : ≥99.0%

Density: 1.091g/cm3

Melting point:>98℃

Boiling Point: 562.9℃ at 760 mmHg

Flash Point: 308.3℃

Refractive Index: 1.529

Vapor Pressure: 0mmHg at 25°C

PSA: 77.7600

LogP: 5.1140

Solubility: Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly);

Category: Standards; Steroids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;


Safety Information:

HS Code: 2918990090


Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.


Application: 

1. 6α-ethyl-chenodeoxycholic acid has been known as INT-747. It is undergoing development as a pharmaceutical agent for several liver diseases and related disorders;

2. It is a derivative of the bile acid Chenodeoxycholic Acid. 


Our factory manufacture’s Obeticholic Acid  mature technology, stable output, quality assurance.

Inventory Status : In Stock.


We can provide 6-Ethylchenodeoxycholic aicd certificate of analysis( COA), CAS 459789-99-2 Method of Analysis (MOA),  Route of synthesis (ROS), (3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-oic acid Material Safety Data Sheet (MSDS) and other support for you !



Obeticholic Acid  also known as 6-ethylchenodeoxycholic acid, is a new derivative of chenodeoxycholic acid (CDCA) in human primary bile acids. It is a farnesoid derivative X receptor (FXR). ) Of natural ligands. Obeticholic acid is a farnesoid X receptor agonist, which indirectly inhibits the gene expression of cytochrome 7A1 (CYP7A1) by activating the farnesoid X receptor. Because CYP7A1 is the rate-limiting enzyme of bile acid biosynthesis, obeticholic acid can inhibit bile acid synthesis and is used to treat primary biliary cirrhosis and non-alcoholic fatty liver disease. 


Obeticholic acid was successfully developed by Intercept Pharmaceuticals in the United States. It is the first drug developed for the treatment of cholestatic liver disease in 20 years. The study is for patients who do not adequately respond or cannot tolerate the old standard treatment drug ursodeoxycholic acid. 


Application
Drug IndicationObeticholic acid is a synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR) that is used to treat liver diseases including primary biliary cirrhosis. 
Formulations/Preparations5 mg, 10 mg
Handling and storage
Safety and HazardsAvoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Handling and storageKeep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: Store at -20°C
Keep in a dry place.
Sample packageAluminium foil bag
Commercial packageAluminium tins
UN Code Not classfied
HS Code29181990
Shipping groupShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Sales restrictionNO
OriginChina


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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.


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