Nintedanib CAS 656247-17-5

Nintedanib CAS 656247-17-5

CAS NO:656247-17-5
Molecular Formula:C31H33N5O4
Molecular Weight:539.625
EINECS NO:1592732-453-0
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Product Details

Product Description

Product Name: Nintedanib CAS NO: 656247-17-5




Ofev; Uritos;





methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;


(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate;



Chemical & Physical Properties

Appearance : Light Yellow to Light Green Solid

Assay :≥99.0%


Boiling Point: 742.2℃ at 760 mmHg

Flash Point:402.7℃

Refractive Index:1.658



Nintedanib, marketed under the brand names Ofev and Vargatef, is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.

Common side effects include abdominal pain, vomiting, and diarrhea. It is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).

It was developed by Boehringer Ingelheim. At an assumed cost of 39,300 pounds per year it does not appear to be cost effective for IPF in the United Kingdom.



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