N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine CAS 1421372-66-8

N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine CAS 1421372-66-8

CAS NO:1421372-66-8
Molecular Formula:C25H31N7O
Molecular Weight:445.56
EINECS NO:N/A
MDL NO:MFCD28167800
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Product Details

Product Description

Product Name: N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine CAS NO: 1421372-66-8

 

 

Synonyms:

AZD9291 intermediate 3;

1,2,4-Benzenetriamine, N-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-;

N-[2-(Dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine;

N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N 1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine;;

 

 

Chemical & Physical Properties

Appearance : Yellow Solid.

Assay : ≥99.0%

 

 

Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

 

 

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