N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-QuinazolinAmine CAS 314771-88-5

N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-QuinazolinAmine CAS 314771-88-5

CAS NO:314771-88-5
Molecular Formula:C18H14ClFN4O4
Molecular Weight:404.78
EINECS NO:925-395-5
MDL NO: N/A
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Product Details

Product Description

Product Name: N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-QuinazolinAmine CAS NO:314771-88-5

 

 

Synonyms:

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-;

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine;

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[(3S)-tetrahydro-3-furanyloxy]-4-quinazolinamine;

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine;

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[(tetrahydrofuran-3-yl)oxy]quinazolin-4-amine;

4-[(3-Chloro-4-fluorophenyl)amino]-6-nitro-7-((5)-tetrahydrofuran-3-yloxy)-quinazoline;

(2Z)-Afatinib intermediate;

 

 

Chemical & Physical Properties

Appearance :Yellow powder.

Assay : ≥99.0%, EE ≥99.5%

Density: 1.5 g/cm3

Boiling Point:585℃ at 760 mmHg

Flash Point:307.6℃

 

 

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

 

 

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