Lifitegrast CAS 1025967-78-5

Lifitegrast CAS 1025967-78-5

CAS NO: 1025967-78-5
Molecular Formula: C29H24Cl2N2O7S
Molecular Weight: 615.48
EINECS NO: 813-044-8
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Product Details

Product Description

Product Name: Lifitegrast CAS NO: 1025967-78-5




L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-;




Lifitegrast(SAR 1118);



Chemical & Physical Properties

Appearance : white to off-white solid.

Assay : ≥99.0%



Lifitegrast is an antagonist of leukocyte functional antigen 1, which is used to treat dry eye. Lifetegras can bind to leukocyte functional antigen-1 (LFA-1) and prevent the binding of LFA-1 to its homologous ligand intercellular adhesion molecule-1 (ICAM-1). The overexpression of ICAM-1 in cornea and conjunctiva of patients with dry eye disease. The combination of lfachemic Book-1 and ICAM-1 promotes the formation of immune synapses, which leads to the activation of T cells and their migration to target tissues. In vitro studies showed that lifegrant could inhibit the adhesion of T cells to ICAM-1 and the secretion of inflammatory cytokines in human peripheral blood monocytes. The exact mechanism of lifegras in the treatment of dry eye remains unclear.



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