Ledipasvir CAS 1256388-51-8

Ledipasvir CAS 1256388-51-8

CAS NO: 1256388-51-8
Molecular Formula: C49H54F2N8O6
Molecular Weight: 889.00
EINECS NO: N/A
MDL NO: MFCD25976756
Chat Now

Product Details

Product Description:

Product Name: Ledipasvir CAS NO:1256388-51-8

 

Synonyms:

GS-5885;

Methyl N-[(2S)-1-[(6S)-6-[5-[9,9-Difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate;

 

Chemical & Physical Properties:

Appearance : white to off-white powder

Assay :≥99.0%

Density:1.4 g/cm3

 

Ledipasvir (formerly GS-5885) is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. After completing Phase III clinical trials, on February 10, 2014 Gilead filed for U.S. approval of a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without PEG-interferon or ribavirin.

Ledipasvir is an inhibitor of the hepatitis C virus NS5A protein.

Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of the nucleotide analog inhibitor sofosbuvir, ledipasvir, and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both treatment-naive patients and prior non-responders with HCV genotype 1. The sofosbuvir/ledipasvir coformulation is being tested with and without ribavirin. In February 2014 Gilead has filed for United States Food and Drug Administration (FDA) approval of ledipasvir/sofosbuvir oral treatment, without interferon and ribavirin.

On October 10, 2014 the FDA approved the combination product ledipasvir/sofosbuvir called Harvoni.

 

 

If you are interested in our products or have any questions, please feel free to contact us!

 

 

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

 

 


Hot Tags: ledipasvir cas 1256388-51-8, manufacturers, suppliers, factory, buy, in stock, CAS 290815-26-8, CAS 1809249-37-3, CAS NO:5856-62-2, 5-chloro-2-pentanone, Eltrombopag Olamine, 3,4-dihydro-2H-pyrrol-5-amine Hydrochloride

Inquiry

You Might Also Like