Darolutamide CAS 1297538-32-9

Darolutamide CAS 1297538-32-9

CAS NO: 1297538-32-9
Molecular Formula: C19H19ClN6O2
Molecular Weight: 398.846
EINECS NO: 829-313-8
MDL NO: MFCD29472270
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Product Details


Product Description:

Product Name: Darolutamide CAS NO:1297538-32-9

 

Synonyms:

ODM-201;

N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide;

 

Chemical & Physical Properties:

Appearance: Light Yellow Liquid

Assay : ≥99.0%

Density:1.4 g/cm3

Boiling Point:719.5℃ at 760 mmHg

Flash Point:388.9℃

 

 

ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.

 

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

 


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