Cangrelor CAS 163706-06-7

Cangrelor CAS 163706-06-7

CAS NO: 163706-06-7
Molecular Formula: C17H25Cl2F3N5O12P3S2
Molecular Weight: 776.359
EINECS NO: N/A
MDL NO: MFCD09837758
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Product Details

Product Description:

Product Name: Cangrelor CAS NO: 163706-06-7

 

Synonyms:

[dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid;

 

Chemical & Physical Properties:

Appearance : White powder

Assay :≥99.0%

Density:2.087g/cm3

Boiling Point:979.0℃ at 760 mmHg

Flash Point:545.882℃

 

 

Cangrelor (trade name Kengreal in the US and Kengrexal in Europe) is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application. Some P2Y12 inhibitors are used clinically as effective inhibitors of adenosine diphosphate-mediated platelet activation and aggregation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion.

Poor interim results led to the abandonment of the two CHAMPION clinical trials in mid-2009. The BRIDGE study, for short term use prior to surgery, continues. The CHAMPION PHOENIX trial was a randomized study of over 11,000 patients published in 2013. It found usefulness of cangrelor in patients getting cardiac stents. Compared with clopidogrel given around the time of stenting, intravenous ADP-receptor blockade with cangrelor significantly reduced the rate of stent thrombosis and myocardial infarction. Reviewers have questioned the methodology of the trial.

 

 

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