Azelastine Hydrochloride CAS 79307-93-0

Azelastine Hydrochloride CAS 79307-93-0

CAS NO: 79307-93-0 (58581-89-8 Azelastine)
Molecular Formula: C22H25Cl2N3O
Molecular Weight: 418.36
EINECS NO: 620-469-0 (253-720-4 Azelastine)
MDL NO: MFCD00242783
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Product Details

Product Description:

Product Name: Azelastine hydrochloride CAS NO: 79307-93-0


Synonyms:

4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride;

4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride;



Chemical & Physical Properties:

Appearance : White to Off-White powder.

Assay : ≥99.0%

Density: 1.25g/cm3

Melting point: 225-229℃

Boiling Point: 533.9℃ at 760 mmHg

Flash Point: 276.7℃

Refractive Index: N/A

Vapor Pressure: 0.0mmHg at 25°C

PSA: 38.13000

LogP: 5.03740

Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol, Water (Slightly), Incompatible with strong oxidizing agents.

Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;


Safety Information:

HS Code: 2933990099


Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.


Application:

1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride and its major metabolites are histamine H1 receptor antagonists with antihistamine effects.


Our factory manufacture’s Azelastine hydrochloride CAS 79307-93-0, mature technology, stable output, quality assurance.

Inventory Status : In Stock.


We can provide 1(2H)-Phthalazinone,4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-,hydrochloride COA (certificate of analysis), CAS 79307-93-0 MOA (Method of Analysis),4-[(4-Chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)phthalazin-1-one Hydrochloride ROS (Route of synthesis),  MSDS (Material Safety Data Sheet) and other support for you !



Azelastine HCl is a potent, second-generation, selective, histamine antagonist.Target: Histamine ReceptorAzelastine is a selective H(1)-receptor antagonist that inhibits histamine release and interferes with activation of several other mediators of allergic inflammation. Azelastine can inhibit CHMCs activation and release of IL-6, tryptase, and histamine. On an equimolar basis, azelastine was a more potent inhibitor than olopatadine . Topical azelastine progressively improved itching and conjunctival redness in PAC patients compared to placebo and was at least as effective as levocabastine. Rapid relief is consistent with H(1)-receptor antagonist action, while continued improvement up to 6 weeks may be consistent with mechanisms involving other mediators of allergic inflammation . Azelastine nasal spray was reported to control all rhinitis symptoms, including nasal congestion, regardless of rhinitis diagnosis during the 2-week study period. Patients with seasonal allergic rhinitis and patients with seasonal allergic rhinitis plus nonallergic triggers were identified as patient types most likely to respond to azelastine nasal spray .


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