Allopurinol CAS 315-30-0

Allopurinol CAS 315-30-0

CAS NO: 315-30-0
Molecular Formula:C5H4N4O
Molecular Weight:136.111
EINECS NO: 206-250-9
MDL NO: MFCD00599413
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Product Details

Product Description

Product Name: Allopurinol CAS NO: 315-30-0




Pural; Apurin;4-HPP;Anzief;HPP;


4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-;

aloral; 4-Hydroxypyrazolo[3,4-d]pyrimidine;



1H-Pyrazolo(3,4-d)pyrimidin-4-ol (4-Hydroxypyrazolo(3,4-d)pyrimidine;




Chemical & Physical Properties

Appearance : White to Off-White powder

Assay : ≥99.0%, GMP/DMF




Boiling Point

290.8ºC at 760 mmHg

Melting Point


Flash Point


Refractive Index


Water Solubility

0.35 g/L (25 ºC)


Stable under normal temperatures and pressures.

Storage Condition

Store in a tightly closed container. Store in a cool,   dry area away from incompatible substances.

Safety Info



Hazard Class


Safety Statements


HS Code


Packing Group


WGK Germany



UN 2811

Risk Statements

R25; R36/37/38; R43

Hazard Codes




Hazard Declaration

H301; H317

Signal Word


Caution Statement

P280; P301 + P310



Allopurinol, sold under the brand name Zyloprim and generics, is a medication used primarily to treat excess uric acid in the blood and its complications, including chronic gout. It is a xanthine oxidase inhibitor and is administered orally.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.



Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Target: XAOAllopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. It is a xanthine oxidase inhibitor which is administered orally. A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase. The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18–30 hours. For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ribotides, hypoxanthine can be salvaged to the purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides may cause feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis.



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