Adavosertib CAS 955365-80-7

Adavosertib CAS 955365-80-7

CAS NO: 955365-80-7
Molecular Formula: C27H32N8O2
Molecular Weight: 500.59
EINECS NO: 680-342-0
MDL NO: MFCD17215200
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Product Details


Product Description:

Product Name: Adavosertib (MK-1775) CAS NO: 955365-80-7






Chemical & Physical Properties:

Appearance: Yellow solid powder

Assay :≥99.0%

Density:1.293 g/cm3

Boiling Point:723.8℃ at 760 mmHg

Flash Point:391.5℃

Solubility: Soluble in DMSO.


MK-1775, also known as adavosertib, AZD-1775, is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.



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