1,2,3-Triacetyl-5-deoxy-D-ribose CAS 62211-93-2

1,2,3-Triacetyl-5-deoxy-D-ribose CAS 62211-93-2

CAS NO: 62211-93-2
Molecular Formula: C11H16O7
Molecular Weight: 260.241
EINECS NO: 612-957-7
MDL NO: MFCD11519026
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Product Details

Product Description:

Product Name: 1,2,3-Triacetyl-5-deoxy-D-ribose  CAS NO: 62211-93-2


Synonyms:

5-Deoxy-b-D-ribofuranose triacetate;

 

Chemical & Physical Properties:

Appearance :white powder

Assay :99.0%

Density:1.23g/cm3

Boiling Point:315

Melting Point:63-64

Flash Point:136

 

 

Triacetyl ribose is an important intermediate for the synthesis of capecitabine, and the capecitabine bulk drug can be prepared in three steps through a route reported in the literature. According to reports in the literature, the synthesis of triacetyl ribose is mainly based on the following two methods: one is using 1-methyl-5-deoxyribose as an intermediate, and triacetyl ribose is obtained through a two-step reaction; the second is using 5-deoxy-D -Ribose is an intermediate and triacetyl ribose is obtained by one-step acetylation. According to the synthetic method reported above, the prepared triacetyl ribose is a mixture of α and β isomers. The β isomer participates in the next reaction to prepare capecitabine. The α isomer is the impurity produced, and the α is different. The ratio of the structure is 3~30%, and the ratio of the α isomer will not be higher. The pure β isomer can be obtained by column chromatography or recrystallization at this isomer ratio.

 

 

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